Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Medchemexpress LLC LCC-12 (formic) | 3029253-76-4 | 99.9% | 460.57 | 5 MG
LCC-12 formic is a dimer of metformin that targets mitochondrial copper(II), leading to a decrease in the NAD(H) pool and modulation of inflammatory responses. It reduces inflammation in mouse models of bacterial and viral infections and serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming.
- Targets mitochondrial copper(II).
- Decreases the NAD(H) pool.
- Modulates inflammatory responses.
- Reduces inflammation in mouse models of bacterial and viral infections.
- Serves as a tool for investigating metabolic diseases.
- Affects cell plasticity.
- Affects epigenetic programming.
Medchemexpress LLC PKCiota-IN-2 formic | 2230055-52-2 | 99.0% | 402.36 | 25 MG
PKCiota-IN-2 formic is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. It also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively. This product is for research use only.
- Appearance: Solid
- Color: Light yellow to yellow
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: 4°C, sealed storage, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month (sealed, away from moisture and light).
- Solubility (in vitro): DMSO: 100 mg/mL (248.53 mM; requires ultrasonic).
Sigma Aldrich Fine Chemicals Biosciences Formic acid reagent grade, >=95% | 64-18-6 | MFCD00003297 | 4X100ML
Formic acid reagent grade, >=95% | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 4X100ML
Medchemexpress LLC PKCiota-IN-2 formic | 99.04% | 402.36 | 50 MG
PKCiota-IN-2 formic is a potent inhibitor of PKCiota (PKC-ι), with an IC50 of 2.8 nM. It also demonstrates inhibitory activity against PKC-α and PKC-ε, exhibiting IC50s of 71 nM and 350 nM, respectively. This product is intended for research use only and is not for sale to patients.
- Potent inhibition of PKCiota.
- Exhibits inhibitory effects on PKC-alpha and PKC-epsilon.
- Available in various quantities, including solid and solution forms.
Medchemexpress LLC Ivaltinostat (formic) | 98.3% | 473.56 | 1 MG
Ivaltinostat formic is an orally active, potent pan-HDAC inhibitor that features a hydroxamic acid moiety designed to bind zinc at the catalytic pocket. It inhibits deacetylation of histone H3 and tubulin, inducing p53 accumulation and promoting p53-dependent transactivation. This compound enhances the expression of MDM2 and p21 proteins, increases sensitivity of Gemcitabine-resistant cells to therapies, induces apoptosis, and demonstrates anti-tumour effects.
- Potent pan-HDAC inhibitor
- Inhibits deacetylation of histone H3 and tubulin
- Promotes p53-dependent transactivation
- Enhances expression of MDM2 and p21 proteins
- Increases sensitivity of drug-resistant cells
- Induces apoptosis
- Exhibits anti-tumour effects
- Attenuates oxidative stress and inflammation
Medchemexpress LLC LCC-12 formic | 3029253-76-4 | 99.85% | 460.57 | 25 MG
LCC-12 formic is a dimer of metformin that targets mitochondrial copper(II), leading to a decrease in the NAD(H) pool and modulation of inflammatory responses. It reduces inflammation in mouse models of bacterial and viral infections and serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming.
- Targets mitochondrial copper(II).
- Leads to a decrease in the NAD(H) pool.
- Modulates inflammatory responses.
- Reduces inflammation in mouse models of bacterial and viral infections.
- Serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming.
LifeSensors Ubiquitin Mass Spectrometry Kit
Mass spectrometry (MS) proteomics, especially when combined with TUBE technologies for protein enrichment, can be used in several innovative and impactful applications. Quantitatively profiling the ubiquitome can lead to the identification of ubiquitination sites on target proteins, and by extension unveiling the mechanisms of undiscovered E3 ligases with their substrates. MS can also inform small molecule drug discovery for these targets (e.g. PROTACs, molecular glues) by quantitatively reporting on how much target protein is degraded in the presence or absence of a drug candidate. This approach can also greatly aid the discovery and development of novel diagnostic biomarkers for challenging disease targets and development of clinically monitoring disease progression. All these applications require a simple, label-free, rapid ubiquitome approach. This kit is designed to address this for rapid yet reproducible proteomics. *The plate is designed for research use only.
Andwin Scientific Water, HPLC, with 0.1% v/v Formic Acid, 4 L
Water, HPLC, with 0.1% v/v Formic Acid, 4 L
Medchemexpress LLC Ammonium formate | 540-69-2 | MFCD00013103 | 98.5% | 63.06 g/mol | CH5NO2 | 50g
Formic acid ammonium salt is an endogenous metabolite
Medchemexpress LLC 5-Propargyltryptamide formic | 2906227-87-8 | 99.9% | 260.29 g/mol | C14H16N2O3 | 10 MG
5-PT formic (5-Propargyltryptamide formic) is a serotonin-derived chemical probe containing a propargyl (alkyne) moiety for copper-catalyzed azide-alkyne cycloaddition (click chemistry). It is used to label and study protein serotonylation in biochemical and cell-based assays.
- Enables copper-catalyzed click chemistry labeling of serotonylated proteins.
- High chemical purity (99.91%).
- Solid, white to off-white physical form for easy handling and storage.
- Suitable for biochemical and cell-based assay applications.
- Available in small-scale quantities (for example, 10 mg) for exploratory studies.
Medchemexpress LLC PKCiota-IN-2 formic | 99.0% | 402.36 | 100 MG
PKCiota-IN-2 formic is a potent inhibitor of PKCiota (PKC-ι) with an IC50 of 2.8 nM. It also demonstrates inhibitory activity against PKC-α and PKC-ε.
- Potent PKCiota (PKC-ι) inhibitor.
- Inhibits PKC-α and PKC-ε.
- Available in solid and solution forms.
- Purity: 99.04%.
- For research use only.
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 | 25KG
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 25KG